Which of the following is a characteristic manifestation of pyelonephritis?

Choice A reason: Headache is not a typical symptom of pyelonephritis and is more commonly associated with systemic infections or neurological conditions. Choice B reason: Frequent urination may occur in lower urinary tract infections but is not a hallmark of pyelonephritis, which involves the kidneys. Choice C reason: CVA tenderness is a classic sign of pyelonephritis, indicating inflammation or infection of the kidney. Choice D reason: Chest pain is unrelated to pyelonephritis and more indicative of cardiac or pulmonary issues.