Which of the following is a contraindication for the use of Alteplase?

A. Peptic ulcer is a relative caution but not an absolute contraindication; risk of bleeding should be considered. B. Hypertension is a relative caution; severe uncontrolled hypertension increases bleeding risk, but controlled hypertension is not an absolute contraindication. C. Ischemic stroke within the past 3 months is a relative contraindication; caution is needed due to increased risk of hemorrhagic conversion. D. Active internal bleeding is an absolute contraindication for alteplase because it is a thrombolytic agent. Administering it in the presence of active bleeding can lead to life-threatening hemorrhage.