Which of the following is a FDA-approved labeled indication for chlorhexidine?

A. Chlorhexidine possesses broad-spectrum antimicrobial activity but is not a primary treatment for oral herpes virus. It does not inhibit viral DNA polymerase like acyclovir. This agent is not FDA-approved for the management of viral infections. B. Gingivitis is a labeled indication for chlorhexidine gluconate oral rinse. It provides antimicrobial activity by disrupting the plasma membrane of bacterial cells. This reduces dental plaque and gingival inflammation between dental visits. C. Vaginal candidiasis is typically managed with antifungal agents like fluconazole or miconazole. Chlorhexidine is not indicated for the treatment of fungal infections within the vaginal vault. Its therapeutic use is restricted to topical or oral mucosal applications. D. Cryptococcal meningitis is a severe fungal infection of the central nervous system requiring systemic amphotericin B. Chlorhexidine does not cross the blood-brain barrier and lacks the necessary systemic distribution. It is not an approved treatment for meningitis.