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    Pharmacology proctored exam 6123 - Chicago state university

    Which of the following is a therapuetic drug class for fluconazole?

    Explanation & Rationale

    A. Fluconazole is a triazole antifungal agent that selectively inhibits the fungal cytochrome P450 enzyme 14-alpha-demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, a critical component of the fungal cell membrane. The resulting membrane instability leads to fungistatic activity. B. Antipsychotic medications typically target dopaminergic or serotonergic receptors in the central nervous system to manage psychosis. Fluconazole lacks affinity for these neural receptors and does not modulate dopamine levels. It is not indicated for the treatment of psychiatric disorders. C. Antilipemic agents, such as statins, inhibit HMG-CoA reductase to lower systemic cholesterol levels in humans. While fluconazole affects sterol synthesis in fungi, it does not significantly impact human lipid metabolism at therapeutic doses. It is not used to treat hyperlipidemia. D. Antibacterial drugs target specific prokaryotic structures or processes, such as the 70S ribosome or peptidoglycan cell wall synthesis. Fluconazole is ineffective against bacteria because they do not utilize ergosterol in their membranes. It is strictly categorized as an antifungal agent.

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