Which of the following is an FDA-approved labeled indication for levofloxacin? Select all that apply.

A. Levofloxacin is indicated for complicated urinary tract infections, including pyelonephritis, caused by susceptible Gram-negative bacilli like Escherichia coli. It achieves high renal concentrations, effectively inhibiting bacterial DNA gyrase and topoisomerase 4. This bactericidal action is essential for treating deep-seated renal parenchyma infections. B. Tetanus is caused by the toxin tetanospasmin from Clostridium tetani, requiring metronidazole or penicillin G for antimicrobial therapy. Levofloxacin is not an FDA-approved treatment for this neurological condition. The management primarily involves wound debridement, antitoxin administration, and supportive care for muscle spasms. C. Herpes zoster is a viral infection resulting from the reactivation of the varicella-zoster virus within sensory ganglia. Levofloxacin is a fluoroquinolone antibiotic and possesses no inhibitory activity against viral DNA polymerase. Antiviral agents like acyclovir or valacyclovir are the standard pharmacological interventions for this condition. D. This agent is FDA-approved for community-acquired pneumonia due to its broad-spectrum activity against Streptococcus pneumoniae and atypical pathogens. It provides excellent lung tissue penetration and inhibits the supercoiling of bacterial DNA. The question stem targets specific labeled indications, which include this respiratory infection.