Which of the following is the proper treatment strategy for medication-overuse headache?
Explanation & Rationale
A. Increase the analgesic dose and frequency: Increasing the dose or frequency of the offending medication worsens medication-overuse headache (MOH) by perpetuating the cycle of rebound headaches. Escalation of analgesics is contraindicated. B. Abruptly discontinue offending agent: While abrupt discontinuation may be necessary in some cases, it often leads to severe withdrawal headaches and other adverse effects. A structured taper is generally safer and better tolerated, especially for opioids, triptans, or combination analgesics. C. No treatment is warranted, as the headache is self-limiting: MOH will not resolve spontaneously without intervention. Continuing the overused medication maintains the headache cycle, so active management is required. D. Taper and subsequently eliminate offending agent: Gradually tapering and eliminating the overused analgesic allows the central nervous system to adjust and break the rebound headache cycle. This strategy reduces withdrawal severity and is supported by clinical guidelines as the safest and most effective approach to treat MOH.