Which of the following medications exerts its effects by inhibiting the conversion of angiotensin I to angiotensin II, is typically used to treat hypertension or congestive heart failure, and has dry cough as a common side effect?
Explanation & Rationale
Choice A reason: Telmisartan is an angiotensin II receptor blocker (ARB), which prevents angiotensin II from binding to its receptors. It does not inhibit the conversion of angiotensin I to II and is less likely to cause a dry cough. Choice B reason: Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. It blocks the conversion of angiotensin I to angiotensin II, reducing vasoconstriction and aldosterone secretion. A common side effect is a persistent dry cough due to increased bradykinin levels. Choice C reason: Amlodipine is a calcium channel blocker that reduces blood pressure by relaxing vascular smooth muscle. It does not affect the renin-angiotensin system and does not cause dry cough. Choice D reason: Furosemide is a loop diuretic that acts on the ascending loop of Henle to promote sodium and water excretion. It is used in heart failure and edema but does not influence angiotensin conversion or cause dry cough.