Which of the following medications exerts its effects by inhibiting the conversion of angiotensin I to angiotensin II, is typically used to treat hypertension or congestive heart failure, and has dry cough as a common side effect?
Explanation & Rationale
Choice A reason: Telmisartan is an angiotensin II receptor blocker (ARB), which prevents angiotensin II from binding to its receptors but does not inhibit its formation. ARBs are less likely to cause a dry cough because they do not increase bradykinin levels. Choice B reason: Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. It blocks the conversion of angiotensin I to angiotensin II, reducing vasoconstriction and aldosterone secretion. A common side effect is a persistent dry cough due to increased bradykinin levels, making it the correct answer. Choice C reason: Amlodipine is a calcium channel blocker that works by relaxing vascular smooth muscle to lower blood pressure. It does not affect the renin-angiotensin system and is not associated with dry cough. Choice D reason: Furosemide is a loop diuretic that inhibits sodium and chloride reabsorption in the loop of Henle. It is used to manage fluid overload in heart failure and hypertension but does not act on the renin-angiotensin system or cause dry cough.