Which of the following medications is most commonly used to treat acute migraine attacks?

A. Triptans: Triptans are selective serotonin receptor agonists that constrict cranial blood vessels and reduce inflammation, directly relieving acute migraine symptoms. They are first-line therapy for moderate to severe migraine attacks and provide rapid symptom relief, including headache and associated nausea or sensitivity to light. B. Antidepressants: Antidepressants, such as amitriptyline, are primarily used for migraine prevention rather than acute treatment. They modulate neurotransmitters to reduce migraine frequency over time but do not provide immediate relief during an active attack. C. Antibiotics: Antibiotics have no role in treating migraines because migraine pathophysiology is neurologic and vascular, not infectious. Using antibiotics would not alleviate pain or associated migraine symptoms and could contribute to unnecessary side effects. D. Beta-blockers: Beta-blockers, such as propranolol, are used for migraine prophylaxis to prevent future attacks, not for acute symptom relief. They work by reducing sympathetic nervous system activity but do not provide immediate relief once a migraine has started.