Which of the following medications should be avoided in children < 16 years old with symptoms of viral infection due to the risk of developing Reye's Syndrome?

A. Acetaminophen (APAP): Acetaminophen is considered safe for fever and pain management in children and does not carry a risk of Reye’s syndrome. It is commonly used as the first-line antipyretic for viral infections in pediatric patients. B. Aspirin (ASA): Aspirin should be avoided in children and adolescents with viral infections because it is strongly associated with Reye’s syndrome, a rare but potentially fatal condition affecting the liver and brain. Alternative antipyretics like acetaminophen or ibuprofen are preferred. C. Naproxen (NSAID): Naproxen is an NSAID that can be used cautiously in children for pain or inflammation. It does not cause Reye’s syndrome but should be dosed appropriately and avoided in certain conditions like renal impairment. D. Ibuprofen (NSAID): Ibuprofen is safe for children for managing fever or mild pain and does not carry the risk of Reye’s syndrome. Proper dosing based on weight is important to avoid gastrointestinal or renal side effects.