Which of the following statements is true regarding common side effects of opioid pain medication?

A. Nausea is a common side effect, and tolerance is unlikely to develop: Opioids commonly cause nausea through stimulation of the chemoreceptor trigger zone and delayed gastric emptying. Tolerance to nausea and vomiting often develops with continued use. Persistence without tolerance is not typical. B. All patients will experience respiratory depression and should avoid chronic use: Respiratory depression is a dose-related adverse effect and is more likely during initiation, dose escalation, or with concurrent CNS depressants. Not all patients experience it, and opioids may be used chronically when appropriately monitored. Individual risk varies based on comorbidities and dosing. C. A prophylactic bowel regimen is needed with a mild stimulant agent: Opioids decrease gastrointestinal motility by activating mu-receptors in the gut, leading to constipation that does not develop tolerance. Prophylactic use of a stimulant laxative, often with a stool softener, is standard practice. Preventive management is essential rather than reactive treatment. D. Sedation will rarely occur when opioids are taken with a full meal: Sedation is a common central nervous system effect of opioids and is not reliably prevented by food intake. Meals may slow absorption but do not eliminate sedative effects. CNS depression can still occur regardless of timing with food.