Which of the four classes of medications used for panic disorder is considered the safest because of its low incidence of side effects and lack of physiologic dependence?

Choice A reason: Monoamine oxidase inhibitors are not considered safe due to dietary restrictions and risk of hypertensive crisis. They are rarely used for panic disorder today. Choice B reason: Selective serotonin reuptake inhibitors (SSRIs) are the safest option because they have a low incidence of side effects, minimal risk of dependence, and strong evidence for efficacy in panic disorder. They are first-line pharmacologic treatment. Choice C reason: Tricyclic antidepressants are effective but have more side effects, including anticholinergic effects, cardiac risks, and overdose potential. Choice D reason: Benzodiazepines are effective for acute relief but carry risks of dependence, tolerance, and withdrawal. They are not considered the safest long-term option.