Which of the two following medication classes are useful in the treatment of fibromyalgia? SELECT TWO

Rationale: A. Tricyclic Antidepressants (TCA) is correct because TCAs, such as amitriptyline, can help reduce pain, improve sleep, and manage fatigue in fibromyalgia by modulating neurotransmitters involved in pain perception. B. Serotonin-norepinephrine reuptake inhibitors (SNRI) is correct because SNRIs, such as duloxetine and milnacipran, are effective in reducing chronic pain, improving mood, and enhancing overall function in fibromyalgia patients. C. Bisphosphonates is incorrect because these medications are used to treat osteoporosis by inhibiting bone resorption and do not address the chronic pain or central sensitization seen in fibromyalgia. D. Anticholinergics is incorrect because these medications affect acetylcholine receptors and are primarily used for conditions like Parkinson’s disease or overactive bladder, with no evidence supporting their use in fibromyalgia management.