Which physiological process supports the exchange of blood concentrations across a semipermeable membrane in the hemodialysis?
Explanation & Rationale
Hemodialysis is a renal replacement therapy used to remove waste products and excess fluid from the blood when the kidneys are unable to perform this function adequately. The physiological processes involved in hemodialysis include: A) Solute movement toward a solution with a higher concentration: While solute movement occurs during hemodialysis, it is typically from a solution with a higher concentration to one with a lower concentration, rather than the opposite. This movement facilitates the removal of waste products and excess solutes from the bloodstream. B) Water movement toward a solution with a lower solute concentration: Correct. Osmosis is the movement of water across a semipermeable membrane from an area of lower solute concentration to an area of higher solute concentration. In hemodialysis, water moves out of the bloodstream, across the semipermeable membrane of the dialyzer, and into the dialysate solution, which has a lower solute concentration. This process helps remove excess fluid from the body. C) Blood cells and protein movement through the semipermeable membrane: Blood cells and proteins are too large to pass through the pores of the semipermeable membrane in the dialyzer during hemodialysis. Therefore, the primary exchange occurs between smaller molecules such as urea, creatinine, electrolytes, and water. D) Osmosis of water movement and diffusion of solute movement: Correct. Hemodialysis involves both osmosis and diffusion. Osmosis refers to the movement of water across a semipermeable membrane from an area of lower solute concentration to an area of higher solute concentration. Diffusion is the movement of solutes from an area of higher concentration to an area of lower concentration. Together, these processes facilitate the removal of waste products and excess fluid from the bloodstream during hemodialysis.