Which potential reaction causes the most concern when administering medication to a patient with decreased albumin and globulin levels?.

Choice A rationale: An increase in the amount of lipid-soluble drugs in the system can occur with decreased albumin and globulin levels, but it does not cause the most concern. Choice B rationale: Increased free protein-bound drugs available can lead to an increased potential for adverse drug reactions. This is because these drugs are usually more active and can lead to toxicity. Choice C rationale: Water-soluble drugs being absorbed more completely is not typically a concern with decreased albumin and globulin levels. Choice D rationale: While metabolism of protein-bound drugs may be decreased, leading to an increased potential for adverse reactions, this is not the primary concern with decreased albumin and globulin levels.