Which statement about food and drug interactions is true?

Choice A reason: Patient preference is not a primary concern in food-drug interactions; physiological effects are. Grapefruit’s impact on metabolism is significant, so this is incorrect for the true statement. Choice B reason: Foods can alter absorption and metabolism, but some also affect drug action (e.g., tyramine with MAOIs). This statement is incomplete, making it incorrect compared to grapefruit’s specific effect. Choice C reason: Grapefruit inhibits CYP isoenzymes, altering drug metabolism and increasing drug levels. This is a well-documented interaction, making it the correct true statement about food-drug interactions. Choice D reason: Not all medications are best absorbed with food; some require empty stomachs. Grapefruit’s metabolic interaction is more accurate, so this is incorrect for the true statement.