Which statement correctly describes a potential disadvantage of the intravenous (IV) route of administration?

A. IV route allows for only 3 mL of drug to be administered: The limitation of small volumes applies more specifically to intramuscular injections depending on the site, not to intravenous administration. The IV route can accommodate large volumes of fluids and medications, including continuous infusions. It is used when rapid administration of significant fluid volumes is required. B. Due to liver metabolism, the exact amount of drug received by the patient is unknown: Intravenous administration bypasses first-pass hepatic metabolism, delivering 100% bioavailability directly into systemic circulation. This allows precise control over dosing and predictable plasma drug concentrations. C. Drug cannot be easily retrieved once injected: Once a medication is administered intravenously, it enters systemic circulation immediately and cannot be withdrawn. Any dosing error or adverse reaction may have rapid and potentially serious consequences. This irreversible nature increases the risk associated with administration errors compared to other routes. D. This route is more likely to irritate the gastrointestinal (GI) tract: Gastrointestinal irritation is associated with oral medications that directly contact the gastric mucosa. The IV route bypasses the GI tract entirely and therefore does not cause local gastric irritation. Instead, IV medications may cause local venous irritation or phlebitis.