Which statement correctly describes an important nursing consideration when dealing with pediatric clients?

A. All drug dosing needs to be weight-based: Pediatric pharmacotherapy requires careful calculation of drug doses based on body weight (mg/kg) or body surface area to ensure therapeutic effectiveness while minimizing the risk of toxicity. Children have differences in metabolism, organ function, and body composition compared with adults, so standard adult dosing may be unsafe or ineffective. B. Newborns have much less total body water than adults: In fact, newborns have a higher percentage of total body water (approximately 70–80%) compared with adults (about 60%). This affects the volume of distribution for water-soluble drugs, often requiring higher mg/kg doses to achieve therapeutic plasma concentrations. C. Pediatric clients can be treated the same as adult clients: Children are not simply “small adults.” Physiologic differences, including immature liver and kidney function, altered protein binding, and variable enzyme activity, influence drug absorption, distribution, metabolism, and excretion. Adult dosing can be unsafe or ineffective in pediatric patients. D. Avoid drugs listed in the Beers Criteria: The Beers Criteria applies specifically to older adults, highlighting potentially inappropriate medications for those aged 65 and older. While caution is always necessary in pediatrics, the Beers list is not relevant to pediatric nursing considerations.