Which statement indicates a correct understanding of topical drug absorption in a pediatric patient?.

Choice A rationale: While it’s true that hydration affects skin absorption, it’s not accurate to say that water-soluble drugs are not readily absorbed because the skin is not fully hydrated. Choice B rationale: Inflammation can actually increase the amount of drug absorbed due to increased blood flow and permeability. Choice C rationale: Topical administration with percutaneous absorption can be effective in infants, but it’s not always the case. Choice D rationale: Infants wearing plastic-coated diapers are indeed more susceptible to skin absorption. This is because the occlusive nature of the diaper can enhance absorption by increasing the hydration of the skin.