Which statement is true regarding general principles of neurotransmission in ADHD?

A. When both Dopamine DA and Norepinephrine NE are too low, the strength of signal output in the prefrontal cortex is high: Low dopamine and norepinephrine levels actually weaken prefrontal cortex signaling rather than heighten it. This leads to a poor ability to sustain attention and control behavior. B. When both Serotonin and GABA are too low, the strength of signal output in the prefrontal cortex is high: Serotonin and GABA are not the primary neurotransmitters involved in ADHD pathophysiology. Their deficiency affects mood and inhibition, not core attention mechanisms. C. When both Dopamine DA and Norepinephrine NE are too low, the strength of signal output in the prefrontal cortex is also too low: Dopamine and norepinephrine facilitate efficient communication in the prefrontal cortex. Low levels reduce cortical signaling strength, leading to distractibility, impulsivity, and difficulty focusing in ADHD. D. When both Serotonin and GABA are too low, the strength of signal output in the prefrontal cortex is also low: Though serotonin and GABA influence arousal and inhibition, their reduction does not directly produce the attentional and executive deficits observed in ADHD.