Which symptom is most commonly associated with Addison's disease due to low cortisol levels?

Choice A reason: Fatigue is one of the most common and early symptoms of Addison’s disease. Cortisol plays a critical role in energy metabolism, stress response, and maintaining blood pressure. When cortisol levels are low, the body struggles to maintain energy balance, leading to persistent fatigue, muscle weakness, and lethargy. This symptom is often reported by patients even before diagnosis and worsens with physical exertion or stress. Choice B reason: Weight gain is not typically associated with Addison’s disease. In fact, many patients experience weight loss due to anorexia, nausea, and gastrointestinal disturbances. The lack of cortisol and aldosterone leads to fluid and electrolyte imbalances that further contribute to weight loss. Choice C reason: Hypertension is more commonly seen in conditions of cortisol excess, such as Cushing’s syndrome. In Addison’s disease, the deficiency of aldosterone leads to sodium loss and volume depletion, often resulting in hypotension rather than hypertension. Choice D reason: Hyperglycemia is associated with cortisol excess, not deficiency. Cortisol promotes gluconeogenesis and increases blood glucose levels. In Addison’s disease, cortisol deficiency leads to impaired glucose production and may even cause hypoglycemia, especially during stress or fasting.