Why does cannabis overdose NOT result in fatal respiratory depression?

A. Cannabis users do not consume opioids: Cannabis use does not preclude concurrent opioid use, and many individuals may use both substances. The absence of fatal respiratory depression from cannabis alone is unrelated to patterns of opioid consumption. B. Cannabinoid receptors increase respiratory drive: Cannabinoids do not stimulate the respiratory center or increase respiratory drive. Their central nervous system effects are primarily modulatory and do not enhance ventilation. This mechanism does not explain the lack of lethal respiratory suppression. C. Cannabinoids have no psychoactive effect: Cannabinoids, particularly THC, have well-documented psychoactive effects, including altered perception, mood changes, and cognitive impairment. Psychoactivity is unrelated to respiratory center depression. D. Cannabinoid receptors are effectively absent in the brainstem and cardiorespiratory centers: CB1 receptors are minimally expressed in the brainstem regions that control respiration and cardiovascular function. Unlike opioids, cannabinoids do not significantly depress the medullary respiratory centers. This neuroanatomical distribution explains why cannabis overdose does not cause fatal respiratory depression.