A. Coma, respiratory alkalosis, and regular pupils: These are not indicative of opioid toxicity. Opioid toxicity typically leads to respiratory depression and constricted pupils. B. Pinpoint pupils, respiratory depression, and coma: This is the classic triad of opioid toxicity. Pinpoint pupils, respiratory depression, and coma are hallmark signs. C. Pinpoint pupils, hypertension, and constipation: Hypertension is not a typical feature of opioid overdose; hypotension is more common. D. Constipation, pupillary dilation, and hypotension: Constipation is common with opioids but pupillary dilation and hypotension are not part of the typical toxicity triad.