A. Fever and chills are more indicative of infection, not Hirschsprung’s disease. B. Severe constipation (along with abdominal distention and failure to pass meconium in newborns) is a hallmark sign of Hirschsprung’s disease due to the absence of ganglion cells in parts of the intestine, causing functional obstruction. C. Jaundice and steatorrhea are associated with liver or biliary disorders, not Hirschsprung’s disease. D. Muscle weakness is not a characteristic symptom of Hirschsprung’s disease.